Dr. Ali B. Ishaque

Professor, Environmental Toxicology, Department of Natural Sciences
University of Maryland Eastern Shore (UMES)

Phone: (410) 651-6050 | Email: abishaque@umes.edu | Fax (410) 651-7739

Curriculum Vitae

  • Member – American Association for the Advancement of Science (AAAS)
  • Editorial Board Member, Journal of Marine Science: Research & Development Open Access
  • Active Member – Society of Toxicology
  • Member – American Association for Cancer Research (AACR)
  • DNS Activity coordinator – Title III 

Education

Free University of Brussels, Belgium (1998)
Ph.D., Ecotoxicology
Free University of Brussels, Belgium (1992)
M.S., Marine Ecology
University of Science & Technology, Kumasi, Ghana (1988)
B.S., Chemistry

Research Interests

  1. Identifying molecular biomarkers for contaminant exposure.
  2. The effects of mixtures of chemical stressors (non-essential metals and stable xenobiotics) on ecosystems.

Selected Publications

  1. Maryam Taabodi, Eric B May, Kelly M Mack, Katherine S Squibb, Ali B Ishaque: Oxidative stress pathways of flavonoid toxicity in human breast tumor cells. Int J Clin Exp Pathol 2017;10(3):2554-2567.
  2. Egbe Egiebor, Adam Tulu, Nadia Abou- Zeid, Ozuem F. Oseji and Ali B. Ishaque: Oxidative Stress Pathway Mechanisms Induced by Four Individual Heavy Metals (As, Hg, Cd and Pb) and Their Quaternary on MCF-7 Breast Cancer Cells: British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 17, Issue.: 7 – DOI:10.9734/BJMMR/2016/27687
  3. Shuiwang Duan, Nianhong Chen,  Sujay S. Kaushal, Paulinus Chigbu, Ali Ishaque, Eric May, Ozuem F. Oseji. Dynamics of dissolved organic carbon and total dissolved nitrogen in Maryland’s coastal bays Estuarine, Coastal and Shelf Science 164 (2015) 451e462
  4. Charles K. Klutse, Egbe S. Egiebor, Isoken T. Aighewi, and Ali B. Ishaque. The Effect of L-Buthionine Sulfoximine on the Toxicities and Interactions of As, Cd, Hg, and Pb and Their Composite Mixture on MCF 7 Cell Line (2015). DOI: 10.9734/BJAST/2015/13509
  5. Nadia Abou-zeid, Egbe Egiebor, Kelly Mack, Katherine Squibb, Isoken Aighewi, Ali Ishaque (2014).   Genotoxicity Effect of Atrazine, Arsenic, Cadmium and Nitrate, Individually and in Mixtures at Maximum Contaminant Level on Breast Cell Lines. J. Afr. Ass. Physiol. Sci. 2 (1): 130-141 (2014)
  6. Isoken Aighewi, Osarodion Nosakhare, Ali Ishaque (2014). Geospatial Evaluation for Ecological Watershed Management II: Changes in Land Use-Land Cover Influence on Ecosystems Services.  Journal of Geographic Information System JGIS: Acceptance Notification [ID: 8401334]
  7. Egbe Egiebor, Adam Tulu, Nadia Abou-Zeid, Isoken Aighewi and Ali Ishaque 2013. The Kinetic Signature of Toxicity of Four Heavy Metals and Their Mixtures on MCF7 Breast Cancer Cell Line Int. J. Environ. Res. Public Health2013, 10(10), 5209-5220; doi:10.3390/ijerph10105209;   http://www.mdpi.com/1660-4601/10/10/5209/
  8. Aighewi, I.T.,Osarodion K. Nosakhare  and Ali B. Ishaque 2012. Land Use-Land Cover Changes and Sewage Loading in the Lower Eastern Shore Watersheds and Coastal Bays of Maryland: Implications for Water Quality. Journal of Coastal Research; doi: 10.2112/JCOASTRES-D-11-00195.1
  9. Nosakhare, O.K.; Aighewi, I.T.; Chi, A.Y.; Ishaque, A.B., and Mbamalu, G., 2012. Land use land cover changes in the lower Eastern Shore watersheds and coastal bays of Maryland: 1986–2006. Journal of Coastal Research, 28(1A), 54–62. West Palm Beach (Florida), ISSN 0749-0208
  10. Charles K. Klutse, Mack Kelly; Squibb, Katherine, Ishaque, Ali (2009). Differential toxicological interaction among arsenic, cadmium, lead and mercury on MCF 7 cell line. Scholarly Research Exchange, Volume 2009 • Article ID 789636 • doi:10.3814/2009/789636
  11. Ali B. Ishaque and Tito I. Aighewi (2008). Dose-Response. In Sven Erik Jergensen and Brian D. Fath    (Editor-in-Chief), Ecotoxicology. Vol [2] of Encyclopedia of Ecology, 5 vols. Pp. [957-967]    Oxford:  Elsevier.
  12. Farah IO, Begum RA, Ishaque AB (2007). Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin. Biomed Sci Instrum 43: 116-21.
  13. Ali B. Ishaque, Linda R. Johnson, Tonya M. Gerald, Dwayne Boucaud, Joseph Okoh, Paul B. Tchounwou (2006). Assessment of Individual and Combined Toxicities of Four Non-Essential Metals (As, Cd, Hg and Pb) in the Microtox.  Int. J. Environ. Res. Public Health 3 (1) 118-120.
  14. Ali B. Ishaque, Eugene L. Bass, Roman Jesien, Steven Hughes, and Carine Hupke (2005) A better method for standardizing vitellogenin content of fish tissue;  Journal of Environmental Biology 26 (1) 1-5
  15. Ali B. Ishaque, Christine Timmons, Frederick V. Ballard, Carine Hupke, Kalpana Dulal, Linda R. Johnson, Tonya M. Gerald, Dwayne Boucaud, Paul B. Tchounwou (2005). Cytotoxicity of Dinitrotoluenes (2,4-DNT, 2,6-DNT ) to MCF-7 and MRC-5 Cells Int. J. Environ. Res. Public Health  2(2), 304-307
  16. Paul B. Tchounwou, Clement G. Yedjou, Dominique N. Foxx, Ali B. Ishaque, Elaine Shen (2004). Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells. Molecular and Cellular Biochemistry 255:161-170.
  17. Ali B. Ishaque, Paul B. Tchounwou, Barbara A. Wilson and Teresa Washington (2004) Developmental arrest in Japanese medaka (Oryzias latipes) embryos exposed to sublethal concentrations of atrazine and arsenic trioxide; Journal of Environmental Biology  25:1, 1-6
  18. Paul B. Tchounwou, Cecilia Newsome, Konsuela Glass, Jose A. Centeno, Jerzy Leszczynski, Joseph Bryant, Joseph Okoh, Ali Ishaque, and Marius Brow (2003) Environmental Toxicology and Health Effects Associated with Dinitrotoluene Exposure. Review on Environ. Health Vol 18:3, 203-229.
  19. Waneene C. Dorsey, Paul B. Tchounwou, Ali B. Ishaque, and Elaine Shen (2002).Transcriptional Activation of Stress Genes and Cytotoxicity in Human Liver Carcinoma (HepG2) Cells Exposed to Pentachlorophenol Int. J. Mol. Sci.3, 992-1007.
  20. P.B. Tchouwnou, A. B. Ishaque, D. Sutton, Nanuli Ninashvili and Elaine Shen (2002). Biomarkers of Sensitivity and effect associated with cadmium and mercury toxicityin human liver carcinoma (HepG2) cells. In Metal Ions in Biology and Medicine. L. Khassanova, Ph. Collery, I. Maymard, Z. Khassanova, J.C. Etienne (Eds) 7:132-137.
  21. Rowshan A. Begum, Ibrahim O. Farah, Ali B. Ishaque (2002). Pifithrin- (PFT-a) caused differential protection of rat liver cells and hepg2 cell line in response to the selective cytotoxicity of arsenic and cadmium. Biomedical Sciences Instrumentation. 38:41-46
  22. P.B. Tchouwnou, A. B. Ishaque, and E. Shen (2001). Cytotoxicity and Stress Genes in Human Liver Carcinoma Cells (HepG2) Exposed to Lead Nitrate. Special Issue, Abstracts of the IXth International Congress of Toxicology, 8-12 July, 2001- Brisbane, Australia. Vol. 164 nos. 1-3: 65. Guest Editor: P.F.A Wright.
  23. P.B. Tchouwnou, A. B. Ishaque, and J. Schneider (2001). Cytotoxicity and Transcriptional Activation of Stress Genes in Human Liver Carcinoma Cells (HepG2) Exposed to Cadmium Chloride. Molecular and Cellular Biochemistry 222:21-28
  24. P.B. Tchouwnou, B. A. Wilson, A. B. Ishaque, and J. Schneider (2001). Atrazine Potentiation of Arsenic Trioxide-Induced Cytotoxicity and Gene Expression in Human Liver Carcinoma Cells (HepG2). Molecular and Cellular Biochemistry 222:49-59.
  25. P.B. Tchounwou, B. Wilson and A. Ishaque (2001). Embryotoxicity of Arsenic Trioxide and Atrazine to Japanese Medaka (Oryzias latipes), and Cytotoxicity to Human Liver Cells (HepG2). Environmental Toxicology and Risk Assessment: Science, Policy and Standardization – Implications for Environmental Decisions: Tenth Volume, ASTM STP 1403: 83-95.
  26. P.B. Tchouwnou, B. A. Wilson, A. B. Ishaque, J. Schneida, (2001). Transcriptional activation of stress genes, and cytotoxicity in human liver carcinoma cells (HepG2) exposed to 2,4,6- Trinitrotoluene, 2,4-Dinitrotoluene, and 2,6- Dinitrotoluene. Environmental Toxicology 16: 209-216.
  27. P.B. Tchouwnou, B. A. Wilson, A. B. Ishaque and D. Sutton (2000). Toxicity evaluation of Arsenic Trioxide and Atrazine to Three Developmental Stages of Japanese Medaka (Oryzias latipes). In Metal Ions in Biology and Medicine. J.A. Centeno, Ph. Collery, G. Vernet, R.B. Finkelman H. Gibb, J.C. Etienne (Eds) 6:18-20

Biosketch

Dr. Ali Ishaque is a Professor of Environmental Science at University of Maryland Eastern Shore (UMES), Princess Anne, MD. He holds a Ph.D in Ecotoxicology and a M.S. degree in Marine Ecology from the Free University of Brussels, Belgium and a B.S. in Chemistry from the University of Science and Technology, Ghana. He is also the Director of the Graduate Toxicology Program, Coordinator of UMES Salisbury University (SU) Environmental Science Dual Degree Program and Group Leader for Environmental Science at UMES. 

Dr. Ishaque’s research interest are: identifying molecular biomarkers for contaminant exposure and the effects of mixtures of chemical stressors (non-essential metals and stable xenobiotics) on ecosystems. His focus is in environmental chemical stressors, especially contaminant of emerging concerns and trophic levels relationship. His research focuses on approaches to understand the impact of environmental stressors on environmental quality, develop innovative tools that address biological and molecular mechanisms of environmental stressors, help to assess risk factors and identify health indicators, and develop and support environmental health policy and promote individual and public health. He is also using Fatty acid markers, stomach content analysis and stable isotope ratios to understand trophic relationships and how food web change in relation to environmental factors and climate variability.

Prior to coming to UMES in August 2001, Dr. Ishaque was a Post-Doctoral Research Associate at Free University of Brussels (VUB), Belgium and at Jackson State University (JSU), Jackson, MS. He is a Board Member of Maryland Coastal Bay Foundation, serves on Advisory Council, Center for the Study of the Health Effects of Fire. Maryland Department of Health and Mental Hygiene. He is also an Editorial Board Member of the Journal of Marine Science: Research & Development- Open Access and Active Member Society of Toxicology. He has published several scientific papers in peer review journals and presented some of his work at national and international scientific meetings.

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